recombinant il 6 ril 6 Search Results


recombinant mouse il-6 protein  (Bio-Techne corporation)
96
Bio-Techne corporation recombinant mouse il-6 protein
Recombinant Mouse Il 6 Protein, supplied by Bio-Techne corporation, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/recombinant mouse il-6 protein/product/Bio-Techne corporation
Average 96 stars, based on 1 article reviews
recombinant mouse il-6 protein - by Bioz Stars, 2026-02
96/100 stars
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ril-6  (Beyotime)
90
Beyotime ril-6
IL-6 is critical for denervation-induced skeletal muscle atrophy. Mice were (s.c.) implanted with Alzet osmotic minipumps for delivering vehicle (saline) plus recombinant murine IL-6 <t>(rIL-6</t> group), vehicle (saline) plus 5 mg/kg (i.p.) tocilizumab, an anti-IL-6 receptor antibody (Den + TCZ group), or vehicle (saline) alone (Den group) for 14 days. After sham operation, mice were administered with vehicle (saline; Ctrl group) for 14 days. Then, the tibialis anterior muscles were harvested to undergo laminin staining analysis. (A) Representative images of laminin-stained tibialis anterior muscle cross-sections in each group. Green indicates laminin staining. Scale bar: 50 µm. (B) The ratio of tibialis anterior muscles wet weight in each group. (C) The mass of tibialis anterior muscles in each group. (D) The cross-sectional area (CSA) in TA fibers in each group. (E) The content of inflammatory cytokine IL-6 in tibialis anterior muscles was determined by ELISA. (F) Representative western blot image of pJAK1/2, pSTAT3, LC3B, BNIP3, PINK1, MHC, MuRF1, and MAFbx in tibialis anterior muscles. (G) Quantification of pJAK1/2, pSTAT3, LC3B, BNIP3, PINK1, MHC, MuRF1, and MAFbx from western blot in tibialis anterior muscles. *, P<0.05; **, P<0.01; and ***, P<0.001 vs. Ctrl. #, P<0.05; ##, P<0.01; and ###, P<0.001 vs. Den + TCZ.
Ril 6, supplied by Beyotime, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ril-6/product/Beyotime
Average 90 stars, based on 1 article reviews
ril-6 - by Bioz Stars, 2026-02
90/100 stars
  Buy from Supplier
mouse recombinant il-6 (ril-6  (Endogen Inc)
90
Endogen Inc mouse recombinant il-6 (ril-6
IL-6 is critical for denervation-induced skeletal muscle atrophy. Mice were (s.c.) implanted with Alzet osmotic minipumps for delivering vehicle (saline) plus recombinant murine IL-6 <t>(rIL-6</t> group), vehicle (saline) plus 5 mg/kg (i.p.) tocilizumab, an anti-IL-6 receptor antibody (Den + TCZ group), or vehicle (saline) alone (Den group) for 14 days. After sham operation, mice were administered with vehicle (saline; Ctrl group) for 14 days. Then, the tibialis anterior muscles were harvested to undergo laminin staining analysis. (A) Representative images of laminin-stained tibialis anterior muscle cross-sections in each group. Green indicates laminin staining. Scale bar: 50 µm. (B) The ratio of tibialis anterior muscles wet weight in each group. (C) The mass of tibialis anterior muscles in each group. (D) The cross-sectional area (CSA) in TA fibers in each group. (E) The content of inflammatory cytokine IL-6 in tibialis anterior muscles was determined by ELISA. (F) Representative western blot image of pJAK1/2, pSTAT3, LC3B, BNIP3, PINK1, MHC, MuRF1, and MAFbx in tibialis anterior muscles. (G) Quantification of pJAK1/2, pSTAT3, LC3B, BNIP3, PINK1, MHC, MuRF1, and MAFbx from western blot in tibialis anterior muscles. *, P<0.05; **, P<0.01; and ***, P<0.001 vs. Ctrl. #, P<0.05; ##, P<0.01; and ###, P<0.001 vs. Den + TCZ.
Mouse Recombinant Il 6 (Ril 6, supplied by Endogen Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/mouse recombinant il-6 (ril-6/product/Endogen Inc
Average 90 stars, based on 1 article reviews
mouse recombinant il-6 (ril-6 - by Bioz Stars, 2026-02
90/100 stars
  Buy from Supplier

Image Search Results


IL-6 is critical for denervation-induced skeletal muscle atrophy. Mice were (s.c.) implanted with Alzet osmotic minipumps for delivering vehicle (saline) plus recombinant murine IL-6 (rIL-6 group), vehicle (saline) plus 5 mg/kg (i.p.) tocilizumab, an anti-IL-6 receptor antibody (Den + TCZ group), or vehicle (saline) alone (Den group) for 14 days. After sham operation, mice were administered with vehicle (saline; Ctrl group) for 14 days. Then, the tibialis anterior muscles were harvested to undergo laminin staining analysis. (A) Representative images of laminin-stained tibialis anterior muscle cross-sections in each group. Green indicates laminin staining. Scale bar: 50 µm. (B) The ratio of tibialis anterior muscles wet weight in each group. (C) The mass of tibialis anterior muscles in each group. (D) The cross-sectional area (CSA) in TA fibers in each group. (E) The content of inflammatory cytokine IL-6 in tibialis anterior muscles was determined by ELISA. (F) Representative western blot image of pJAK1/2, pSTAT3, LC3B, BNIP3, PINK1, MHC, MuRF1, and MAFbx in tibialis anterior muscles. (G) Quantification of pJAK1/2, pSTAT3, LC3B, BNIP3, PINK1, MHC, MuRF1, and MAFbx from western blot in tibialis anterior muscles. *, P<0.05; **, P<0.01; and ***, P<0.001 vs. Ctrl. #, P<0.05; ##, P<0.01; and ###, P<0.001 vs. Den + TCZ.

Journal: Annals of Translational Medicine

Article Title: Inhibition of IL-6/JAK/STAT3 pathway rescues denervation-induced skeletal muscle atrophy

doi: 10.21037/atm-20-7269

Figure Lengend Snippet: IL-6 is critical for denervation-induced skeletal muscle atrophy. Mice were (s.c.) implanted with Alzet osmotic minipumps for delivering vehicle (saline) plus recombinant murine IL-6 (rIL-6 group), vehicle (saline) plus 5 mg/kg (i.p.) tocilizumab, an anti-IL-6 receptor antibody (Den + TCZ group), or vehicle (saline) alone (Den group) for 14 days. After sham operation, mice were administered with vehicle (saline; Ctrl group) for 14 days. Then, the tibialis anterior muscles were harvested to undergo laminin staining analysis. (A) Representative images of laminin-stained tibialis anterior muscle cross-sections in each group. Green indicates laminin staining. Scale bar: 50 µm. (B) The ratio of tibialis anterior muscles wet weight in each group. (C) The mass of tibialis anterior muscles in each group. (D) The cross-sectional area (CSA) in TA fibers in each group. (E) The content of inflammatory cytokine IL-6 in tibialis anterior muscles was determined by ELISA. (F) Representative western blot image of pJAK1/2, pSTAT3, LC3B, BNIP3, PINK1, MHC, MuRF1, and MAFbx in tibialis anterior muscles. (G) Quantification of pJAK1/2, pSTAT3, LC3B, BNIP3, PINK1, MHC, MuRF1, and MAFbx from western blot in tibialis anterior muscles. *, P<0.05; **, P<0.01; and ***, P<0.001 vs. Ctrl. #, P<0.05; ##, P<0.01; and ###, P<0.001 vs. Den + TCZ.

Article Snippet: In brief, we subcutaneously implanted (s.c.) osmotic minipumps (Alzet Model 2002; Alza Corp., Mountain View, CA, USA) in normal mice in order to infuse rIL-6 (Beyotime, Nantong, China) to their tibialis anterior muscle through a catheter (i.d.

Techniques: Saline, Recombinant, Muscles, Staining, Enzyme-linked Immunosorbent Assay, Western Blot

JAK/STAT3 inhibition blocks IL-6-induced C2C12 myotube atrophy. C2C12 myotubes were treated with 100 ng/mL rIL-6 (rIL-6 group), rIL-6 plus 400 nM ruxolitinib (rIL-6 + Rux group), rIL-6 plus 10 µM C188-9 (rIL-6 + C188-9 group), or with vehicle (DMSO) (Ctrl group). (A) Representative images of MHC-stained C2C12 myotubes and the histogram showing the diameters of C2C12 myotubes. Green indicates MHC staining. Scale bar: 20 µm. ***, P<0.001; and ****, P<0.0001 vs. Ctrl. #, P<0.05 vs. rIL-6. (B) Representative western blot images and the relative expression of pJAK1/2, pSTAT3, MHC, MuRF1, and MAFbx in C2C12 myotubes. *, P<0.05; **, P<0.01; ***, P<0.001; and ****, P<0.0001 vs. Ctrl. #, P<0.05; and ###, P<0.001 vs. rIL-6 + Rux. (C) Representative western blot images and the quantification of pJAK1/2, pSTAT3, MHC, MuRF1, and MAFbx from western blot in C2C12 myotubes. *, P<0.05; **, P<0.01; and ***, P<0.001 vs. Ctrl. #, P<0.05 vs. rIL-6 + C188-9.

Journal: Annals of Translational Medicine

Article Title: Inhibition of IL-6/JAK/STAT3 pathway rescues denervation-induced skeletal muscle atrophy

doi: 10.21037/atm-20-7269

Figure Lengend Snippet: JAK/STAT3 inhibition blocks IL-6-induced C2C12 myotube atrophy. C2C12 myotubes were treated with 100 ng/mL rIL-6 (rIL-6 group), rIL-6 plus 400 nM ruxolitinib (rIL-6 + Rux group), rIL-6 plus 10 µM C188-9 (rIL-6 + C188-9 group), or with vehicle (DMSO) (Ctrl group). (A) Representative images of MHC-stained C2C12 myotubes and the histogram showing the diameters of C2C12 myotubes. Green indicates MHC staining. Scale bar: 20 µm. ***, P<0.001; and ****, P<0.0001 vs. Ctrl. #, P<0.05 vs. rIL-6. (B) Representative western blot images and the relative expression of pJAK1/2, pSTAT3, MHC, MuRF1, and MAFbx in C2C12 myotubes. *, P<0.05; **, P<0.01; ***, P<0.001; and ****, P<0.0001 vs. Ctrl. #, P<0.05; and ###, P<0.001 vs. rIL-6 + Rux. (C) Representative western blot images and the quantification of pJAK1/2, pSTAT3, MHC, MuRF1, and MAFbx from western blot in C2C12 myotubes. *, P<0.05; **, P<0.01; and ***, P<0.001 vs. Ctrl. #, P<0.05 vs. rIL-6 + C188-9.

Article Snippet: In brief, we subcutaneously implanted (s.c.) osmotic minipumps (Alzet Model 2002; Alza Corp., Mountain View, CA, USA) in normal mice in order to infuse rIL-6 (Beyotime, Nantong, China) to their tibialis anterior muscle through a catheter (i.d.

Techniques: Inhibition, Staining, Western Blot, Expressing